il 4 (R&D Systems)
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R&D Systems
il 4
Il 4, supplied by R&D Systems, used in various techniques. Bioz Stars score: 96/100, based on 623 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/recombinant+mouse+il+4/Recombinant+Mouse+IL-4+Protein/pm41991935-316-7-9
Average 96 stars, based on 623 article reviews
Il 4, supplied by R&D Systems, used in various techniques. Bioz Stars score: 96/100, based on 623 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/recombinant+mouse+il+4/Recombinant+Mouse+IL-4+Protein/pm41991935-316-7-9
Average 96 stars, based on 623 article reviews
il 4 - by Bioz Stars,
2026-09
96/100 stars
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ChIP-qPCR:Article Title: Targeting MAFB potentiates immune checkpoint inhibitor efficacy by reprogramming tumor-associated macrophages to an M1-like phenotype in colorectal cancer. Article Snippet: Colorectal cancer (CRC) remains largely resistant to immune checkpoint inhibitors (ICIs) due to an immunosuppressive tumor microenvironment (TME) shaped by M2-like tumor-associated macrophages (TAMs).. Identifying transcriptional regulators of M2-like TAMs in CRC could provide strategies to overcome ICI resistance by reprogramming the TME.. In this study, we analyzed single-cell RNA-seq data from CRC patients to identify transcriptional regulators of M2-like TAMs. Recombinant:Article Title: Targeting MAFB potentiates immune checkpoint inhibitor efficacy by reprogramming tumor-associated macrophages to an M1-like phenotype in colorectal cancer. Article Snippet: Colorectal cancer (CRC) remains largely resistant to immune checkpoint inhibitors (ICIs) due to an immunosuppressive tumor microenvironment (TME) shaped by M2-like tumor-associated macrophages (TAMs).. Identifying transcriptional regulators of M2-like TAMs in CRC could provide strategies to overcome ICI resistance by reprogramming the TME.. In this study, we analyzed single-cell RNA-seq data from CRC patients to identify transcriptional regulators of M2-like TAMs. Article Title: Inflammatory arthritis irAE may represent a unique autoimmune disease primarily driven by T cells but likely not autoantibodies Article Snippet: .. Condition 1: LPS (3 μg/ml; Sigma-Aldrich, catalog no. L2880-25MG) and Article Title: Inflammatory arthritis irAE may represent a unique autoimmune disease primarily driven by T cells but likely not autoantibodies. Article Snippet: .. Condition 1: LPS (3 μg/ml; Sigma- Aldrich, catalog no. L288025MG) and Article Title: Engrafted NSG-SGM3 humanized mice spontaneously produce human immunoglobulins including IgE Article Snippet: Erythrocytes were then lysed with 1x multi-species RBC lysis buffer (Invitrogen) and remaining bulk splenocytes were washed and spun. .. Harvested bulk WT, non-engrafted NSG-SGM3, or engrafted NSG-SGM3 splenocytes were initially plated in 6-well flat-bottom plates at 1 x 10 6 cells/mL in supplemented RPMI media as above, and incubated from 0 to 48 hours with either 1 μg/mL mouse anti-human CD40 monoclonal antibody (anti-hCD40; BD Pharmingen) and 10 ng/mL recombinant human IL-4 (hIL-4; R&D Systems) anti-human stimulatory cytokines, or 1 μg/mL hamster anti-mouse CD40 monoclonal antibody (anti-mCD40; BD Biosciences) and 10 ng/mL Article Title: Enhancing effects of Mycoplasma pneumoniae antigens on Th2-attracting chemokine responses by murine splenocytes. Article Snippet: Mycoplasma pneumoniae is an aetiologic agent responsible for primary atypical pneumonia mainly in children and early teens.. The pathogenic mechanisms for M. pneumoniae pneumonia is thought to be multifactorial with contribution from an excessive host immune response.. In this report, we isolated splenocytes, CD4 CD62L cells and CD90.2cells from mouse spleen. Article Title: Longan polysaccharides promote Th1 and Treg cell differentiation via dendritic cells. Article Snippet: In this study, the activating effects of a glucan derived from longan (LP) on primary bone marrow dendritic cells (BMDCs) and their role in mediating T cells differentiation were investigated.. LP significantly reduce phagocytosis in dendritic cells (DCs) while augmenting CD80, CD86, and MHC II surface molecule expression, and promoting the IL-6, IL-10, and IL-12 secretion.. RNA-seq, immunofluorescence, and Western blot analysis indicated that LP primarily activate DC through the Toll-NF-κB pathway, upregulating genes related to maturation and antigen presentation, thereby regulating cytokine release and T cell activation. Lysis:Article Title: Targeting MAFB potentiates immune checkpoint inhibitor efficacy by reprogramming tumor-associated macrophages to an M1-like phenotype in colorectal cancer. Article Snippet: Colorectal cancer (CRC) remains largely resistant to immune checkpoint inhibitors (ICIs) due to an immunosuppressive tumor microenvironment (TME) shaped by M2-like tumor-associated macrophages (TAMs).. Identifying transcriptional regulators of M2-like TAMs in CRC could provide strategies to overcome ICI resistance by reprogramming the TME.. In this study, we analyzed single-cell RNA-seq data from CRC patients to identify transcriptional regulators of M2-like TAMs. Sonication:Article Title: Targeting MAFB potentiates immune checkpoint inhibitor efficacy by reprogramming tumor-associated macrophages to an M1-like phenotype in colorectal cancer. Article Snippet: Colorectal cancer (CRC) remains largely resistant to immune checkpoint inhibitors (ICIs) due to an immunosuppressive tumor microenvironment (TME) shaped by M2-like tumor-associated macrophages (TAMs).. Identifying transcriptional regulators of M2-like TAMs in CRC could provide strategies to overcome ICI resistance by reprogramming the TME.. In this study, we analyzed single-cell RNA-seq data from CRC patients to identify transcriptional regulators of M2-like TAMs. RNA Sequencing:Article Title: Targeting MAFB potentiates immune checkpoint inhibitor efficacy by reprogramming tumor-associated macrophages to an M1-like phenotype in colorectal cancer. Article Snippet: Colorectal cancer (CRC) remains largely resistant to immune checkpoint inhibitors (ICIs) due to an immunosuppressive tumor microenvironment (TME) shaped by M2-like tumor-associated macrophages (TAMs).. Identifying transcriptional regulators of M2-like TAMs in CRC could provide strategies to overcome ICI resistance by reprogramming the TME.. In this study, we analyzed single-cell RNA-seq data from CRC patients to identify transcriptional regulators of M2-like TAMs. Incubation:Article Title: Targeting MAFB potentiates immune checkpoint inhibitor efficacy by reprogramming tumor-associated macrophages to an M1-like phenotype in colorectal cancer. Article Snippet: Colorectal cancer (CRC) remains largely resistant to immune checkpoint inhibitors (ICIs) due to an immunosuppressive tumor microenvironment (TME) shaped by M2-like tumor-associated macrophages (TAMs).. Identifying transcriptional regulators of M2-like TAMs in CRC could provide strategies to overcome ICI resistance by reprogramming the TME.. In this study, we analyzed single-cell RNA-seq data from CRC patients to identify transcriptional regulators of M2-like TAMs. Article Title: Engrafted NSG-SGM3 humanized mice spontaneously produce human immunoglobulins including IgE Article Snippet: Erythrocytes were then lysed with 1x multi-species RBC lysis buffer (Invitrogen) and remaining bulk splenocytes were washed and spun. .. Harvested bulk WT, non-engrafted NSG-SGM3, or engrafted NSG-SGM3 splenocytes were initially plated in 6-well flat-bottom plates at 1 x 10 6 cells/mL in supplemented RPMI media as above, and incubated from 0 to 48 hours with either 1 μg/mL mouse anti-human CD40 monoclonal antibody (anti-hCD40; BD Pharmingen) and 10 ng/mL recombinant human IL-4 (hIL-4; R&D Systems) anti-human stimulatory cytokines, or 1 μg/mL hamster anti-mouse CD40 monoclonal antibody (anti-mCD40; BD Biosciences) and 10 ng/mL Flow Cytometry:Article Title: Targeting MAFB potentiates immune checkpoint inhibitor efficacy by reprogramming tumor-associated macrophages to an M1-like phenotype in colorectal cancer. Article Snippet: Colorectal cancer (CRC) remains largely resistant to immune checkpoint inhibitors (ICIs) due to an immunosuppressive tumor microenvironment (TME) shaped by M2-like tumor-associated macrophages (TAMs).. Identifying transcriptional regulators of M2-like TAMs in CRC could provide strategies to overcome ICI resistance by reprogramming the TME.. In this study, we analyzed single-cell RNA-seq data from CRC patients to identify transcriptional regulators of M2-like TAMs. Expressing:Article Title: Targeting MAFB potentiates immune checkpoint inhibitor efficacy by reprogramming tumor-associated macrophages to an M1-like phenotype in colorectal cancer. Article Snippet: Colorectal cancer (CRC) remains largely resistant to immune checkpoint inhibitors (ICIs) due to an immunosuppressive tumor microenvironment (TME) shaped by M2-like tumor-associated macrophages (TAMs).. Identifying transcriptional regulators of M2-like TAMs in CRC could provide strategies to overcome ICI resistance by reprogramming the TME.. In this study, we analyzed single-cell RNA-seq data from CRC patients to identify transcriptional regulators of M2-like TAMs. Real-time Polymerase Chain Reaction:Article Title: Targeting MAFB potentiates immune checkpoint inhibitor efficacy by reprogramming tumor-associated macrophages to an M1-like phenotype in colorectal cancer. Article Snippet: Colorectal cancer (CRC) remains largely resistant to immune checkpoint inhibitors (ICIs) due to an immunosuppressive tumor microenvironment (TME) shaped by M2-like tumor-associated macrophages (TAMs).. Identifying transcriptional regulators of M2-like TAMs in CRC could provide strategies to overcome ICI resistance by reprogramming the TME.. In this study, we analyzed single-cell RNA-seq data from CRC patients to identify transcriptional regulators of M2-like TAMs. Control:Article Title: Enhancing effects of Mycoplasma pneumoniae antigens on Th2-attracting chemokine responses by murine splenocytes. Article Snippet: Mycoplasma pneumoniae is an aetiologic agent responsible for primary atypical pneumonia mainly in children and early teens.. The pathogenic mechanisms for M. pneumoniae pneumonia is thought to be multifactorial with contribution from an excessive host immune response.. In this report, we isolated splenocytes, CD4 CD62L cells and CD90.2cells from mouse spleen. Enzyme-linked Immunosorbent Assay:Article Title: Longan polysaccharides promote Th1 and Treg cell differentiation via dendritic cells. Article Snippet: In this study, the activating effects of a glucan derived from longan (LP) on primary bone marrow dendritic cells (BMDCs) and their role in mediating T cells differentiation were investigated.. LP significantly reduce phagocytosis in dendritic cells (DCs) while augmenting CD80, CD86, and MHC II surface molecule expression, and promoting the IL-6, IL-10, and IL-12 secretion.. RNA-seq, immunofluorescence, and Western blot analysis indicated that LP primarily activate DC through the Toll-NF-κB pathway, upregulating genes related to maturation and antigen presentation, thereby regulating cytokine release and T cell activation. |